Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level

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Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level

Conclusions

The majority of patients with mild, persistent asthma had a low sputum eosinophil level and had no significant difference in their response to either mometasone or tiotropium as compared with placebo. These data provide equipoise for a clinically directive trial to compare an inhaled glucocorticoid with other treatments in patients with a low eosinophil level. (Funded by the National Heart, Lung, and Blood Institute; SIENA ClinicalTrials.gov number, NCT02066298.) NEJM 6/2019